Effective Dosage: There is no clinical evidence that Alpha Lipoic Acid is effective as a diet supplement at any dosage. For the treatment of specific disorders, Alpha lipoic acid is usually taken in doses of 100 to 200 mg three times a day. For general antioxidant support, lower doses of 50 to 150 mg a day may be used.
Alpha lipoic acid affects nearly every cell in the body. It assists all of the B vitamins -- including thiamin, riboflavin, pantothenic acid, and niacin -- in converting carbohydrates, protein, and fats found in foods into energy the body can store and later use. Alpha-lipoic acid is a cell-protecting antioxidant that may help the body recycle other antioxidants, such as vitamins C and E, boosting their potency. Thanks to its unique chemical properties, alpha-lipoic acid is easily absorbed by most tissues in the body, including the brain, nerves, and liver, making it valuable for treating a wide range of ailments.
Encouraging results that Alpha lipoic acid increases weight loss has been documented in rat studies. Korean scientists discovered that alpha-lipoic acid can cause substantial weight loss in obese mice, according to a study published in the July 2004 issue of Nature Medicine.
Researchers treated obese mice with an increased dosage of ALA—more than what has in the past been used to support the health of diabetics. Almost 100 percent of mice lost weight until they reached their normal weight level.adipex
The researchers also investigated the mechanism by which ALA triggers weight loss. AMP-activated protein kinase (AMPK) functions as a fuel sensor in the cell and is activated when cellular energy is depleted. Consequently, it triggers an increase in appetite to bring cellular energy back up to a sufficient level. ALA decreases hypothalamic AMPK activity, reducing food intake and enhancing energy expenditure. When the researchers activated hypothalamic AMPK, on the other hand, the beneficial effects of ALA on food intake and energy expenditure were reversed, indicating that ALA increases weight loss through its effects on AMPK activity.
The researchers concluded that hypothalamic AMPK is important in the regulation of food intake and energy expenditure and that alpha-lipoic acid exerts anti-obesity effects by suppressing hypothalamic AMPK activity. (Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU. Anti-obesity effects of alpha-lipoic acid www.ed by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul;10(7):727-33. Epub 2004 Jun 13. )
There has been no human study conducted that supports that Alpha lipoic acid is effective for weight loss. For More diet pill Information Click Here
Alpha-lipoic acid appears to be very safe, and there have been no reports of serious side effects in people taking it. Occasionally, the supplement may produce mild gastrointestinal upset, and in rare cases, allergic skin rashes have occurred. If side effects appear, lower the dose or discontinue using the supplement.
These statements about Alpha-lipoic acid have not been evaluated by the Food and Drug Administration. ALA is not intended to diagnose, treat, cure, or prevent any disease.
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